Dmytro V. Lytkin
Ph.D, Sc. D. (Biol.), Prof. Andriy L. Zagayko

Ukraine, Kharkiv, National University of Pharmacy



Metabolic syndrome is the common disease that mostly manifests in insulin resistance and dyslipidemia. Sex hormones imbalance caused by increased peripheral aromatase activity is also plays an important role in aggressive clinical behavior of metabolic syndrome with dyslipidemia. We evaluated the influence of third-generation aromatase inhibitors on blood lipids in hamsters of different age and sex with diet-induced metabolic syndrome. Preparations daily dose for hamsters were calculated by the animal equivalent doses coefficient from human therapeutic doses, and the treatment period was 21 days. Treated hamsters with metabolic syndrome had significantly lower serum levels of free fatty acids, triglycerides, total cholesterol and low density lipoproteins cholesterol compared to untreated animals. The most efficiency was indicated in adult male hamsters. Collectively, the results show that aromatase inhibitors had significant moderate effect on dyslipidemia correction in hamsters with diet-induced metabolic syndrome. Although the results of experiment suggest that aromatase inhibitors may be studied in clinical trials as medicines for metabolic syndrome therapy.

Keywords: metabolic syndrome, dyslipidemia, aromatase inhibitors, exemestane, letrozole, anastrozole.


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