THE BASICS APPROACH TO BONE ANTIGEN AND LOCAL IMMUNITY OF ORAL CAVITY AT THE STAGE OF PROSTHETIC SUPPORT OF THE COMPREHENSIVE TREATMENT OF THE GENERALIZED PERIODONTITIS

M.D. Professor Antonenko M.,
PhD Zelinskaya N.,
PhD Znachkova O.,
Revych V.,
Syroyishko M.

Ukraine, Kyiv, Bogomolets National Medical University, Dentistry department

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Abstract.

Generalized periodontitis (HP) occupies one of the leading places in the structure of
dental diseases. The expediency of using certain orthopedic structures at the stages of therapeutic and surgical treatment of GP, the choice of orthopedic structure, its specificity and preference, depending on the degree of severity and nature of the course of GP, the peculiarities of the dentition, and the rational timing of the application of various orthopedic structures, requires scientific justification. To evaluate the results of complex treatment of GP it is advisable to use indicators of specific reactions that objectively reflect the processes occurring in the alveolar process under the influence of the orthopedic Prostetics.
The purpose of this study was to establish the role, place and correspondence of tissue allergy
to bone antigen and the level of local immunity at the stages of orthopedic support in the complex
treatment of GP.
Materials and methods. To achieve this goal, clinical, radiological and immunological methods of investigation were used. To determine the tissue allergy to the bone antigen, the inhibition of migration of leukocytes (RTML) was chosen. The state of local immunity was assessed in saliva according to the level of 11SIgA, 7SIgA, IgM and IgG in the Manchini reaction. The study was based on the dynamic observation of 132 patients with GP of I-II degree with chronic and exacerbated course, taking into account the results of examination of male patients 22-25 years old without a clinically established pathology from the osteoarticular apparatus and diseases of internal organs and systems. As orthopedic structures, non-removable non-invasive temporary spikes based on an inorganic matrix with pre-filled fibers and provisional crowns were selected.
Results and its discussion. As a result of the study, we found a pronounced tissue sensitization
to the bone antigen in 61.05 ± 5.7 % of patients with chronic HA and in 80.0 ± 5.1 % of patients with exacerbated HP with no allergy to the bone antigen in practically Healthy people and does not
significantly depend on the chosen orthopedic Prostetics.
When studying the indices characterizing the state of local immunity in general in patients with GP, a decrease in the immunoglobulin indices of all classes was found in comparison with the control group. An increase in the parameters of secretory immunity with the inclusion of the orthopedic component for 1-1.5 months in the complex treatment of GP depends more on the drug component and does not depend on the chosen orthopedic structure.
Conclusions. High tissue sensitization to the bone antigen in generalized periodontitis objectively reflects the level of the osteoclast process. The absence of a decrease in tissue allergy to bone antigen in the complex treatment of GP, including the orthopedic component, can not correct the failure in recognizing «one’s» — «someone else’s», normalize the distorted response to the antigen load and requires additional inclusion of specific methods, including the immunological component.

Keywords: generalized periodontitis, tissue sensitization to bone antigen, local immunity, orthopedic treatment.

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