REPRODUCTION OF DIABETES MELLITUS` TYPES IN AN EXPERIMENT

M.D., Professor Savytskiy I. V.,
Ph.D., Associate Professor Kuzmenko I. A.,
Postgraduate Sarahan V. M.,
Resident Yakymchuk N. V.

Ukraine, Odessa, Odessa National Medical University

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Abstract.

It is known that patients with diabetes mellitus significantly increase the risk of cardiovascular disease. In recent years, the disease prevalence has been steadily increasing.
Hyperglycemia significantly reduces the quality of life of the patient, reduces his ability to work and life expectancy by 10-30 %. That`s why diabetes mellitus is a heavy socio-economic burden in any country in the world and is ranked one of the top places in the ranking of chronic diseases. The curiosity of scientists is due to high disability of patients with diabetes mellitus and the development of complications.
Of all the experimental methods described in the simulation of experimental diabetes, the most common and recognized in the world are chemical methods (to use a streptotsocin, alloxan, etc.). In fact, many models of diabetes mellitus may be exist. For example, full or partial surgical removal of the pancreas. In the immune model, antibodies are used against insulin, and in the genetic — the removal of pure lines of mice and other animals with a hereditary-conditioned form of diabetes mellitus.

Keywords: experimental model, diabetes mellitus, laboratory animals, alloxan, streptozotocine.

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