DOI: https://doi.org/10.31435/rsglobal_sr/01062018/5615

Кушнарьова Н. М.

Україна, м. Київ, ДУ «Інститут ендокринології та обміну речовин ім. В. П. Комісаренка»



In 60 type 2 diabetic patients with different forms of isolated dyslipidemia, investigated serum lipid profile and fatty acid (FA) spectrum in lipid fractions of free fatty acids, triglycerides and phospholipids. In the groups with isolated hypoalfalipoproteinemia and with isolated hypertriglyceridemia, we found reducing of unsaturated to saturated FA ratio, that may cause difficulty in absorption and utilization of FA in the form of VLDL as energy substrates. The isolated hypercholesterolemia group showed increasing in relative content of polyunsaturated FA in serum lipid fractions that may indicate a disturbance of active uptake of PUFA by cells, causing a deficiency of these structural components in membranes and increasing the risk of atherogenesis.

Keywords: type 2 diabetes, isolated dislipidemia, serum lipoprotein profile, fatty acid spectrum of serum free fatty acids, triglycerides, phospholipids


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